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High-Risk Women Reluctant to Take Tamoxifen for Prevention of Breast Cancer




Despite recent trials showing the effectiveness of tamoxifen in reducing the incidence of breast cancer in high-risk women, this study of 345 women at an elevated risk for developing breast cancer found that few women chose to take it. Of the 89 high-risk women studied, only one decided to take tamoxifen for breast cancer chemoprevention.

Among the 48 women who discussed the option with their family physician, only three family physicians recommended preventive tamoxifen use. Fear of serious side effects, the perception of being at low risk, and the lack of physician recommendation were the most frequently cited factors in patients' decision not to use tamoxifen.
Tamoxifen for Breast Cancer Chemoprevention: Low Uptake by High-Risk Women After Evaluation of a Breast Lump
By Rebecca Taylor, M.D., M.Sc., et al

Annals of Family Medicine is a peer-reviewed research journal that provides a cross-disciplinary forum for new, evidence-based information affecting the primary care discipline. Launched in May 2003, the journal is sponsored by six family medical organizations, including the American Academy of Family Physicians, the American Board of Family Medicine, the Society of Teachers of Family Medicine, the Association of Departments of Family Medicine, the Association of Family Medicine Residency Directors and the North American Primary Care Research Group. Annals is published six times each year and contains original research from the clinical, biomedical, social and health services areas, as well as contributions on methodology and theory, selected reviews, essays and editorials. A board of directors with representatives from each of the sponsoring organizations oversees Annals. Complete editorial content and interactive discussion groups for each published article can be accessed free of charge on the journal's Web site, http://www.annfammed.org.

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